In this light, it is important to note that combined treatment with Brafi, Meki and αPD1 has been recently shown to generate potent therapeutic responses in the transplantable SM1 (BrafV600E) melanoma model11 and that treatment of patients with advanced-stage Braf-mutant melanomas have displayed encouraging responses to treatment with this combination regimen.82 Hence, we also plan to investigate the therapeutic efficacy of skin immunization combined with Brafi+Meki in future studies. This evidence concerns the gene BRAF and melanoma.