Gene gun (GG)-mediated cutaneous immunization with cDNA encoding xbp1 and hsp70 fused to the melanoma-associated antigen TRP2 elicits durable antitumor immunity against BrafV600E/Pten−/− melanomas (figure 1).58 Consistent with findings from others,61 we observed that the conditionally induced melanomas were intrinsically resistant to PD1 blockade monotherapy (figure 1). Here, XBP1 is linked to melanoma.