MPPE1 and melanoma: The current research focus in clinical tumor immunology is mainly centered on TILs and how their function can be restored with checkpoint blockade.2 3 Recently, the importance of DCs for this type of immunotherapy was revealed,5 and several reports demonstrated a dominant role for cDC1 in the cross-presentation of tumor antigens in the tumor microenvironment (TME).6–8 Nevertheless, the role of the migratory skin DC in priming melanoma-specific T cell responses in the tumor-draining LNs is just partly understood.