ITGAM and neoplasm: We previously reported that during tumor progression, MDSCs infiltrate the tumor tissue at a late tumor stage and that they exert immunosuppressive effects.21 In this study, we investigated the immunological changes at earlier tumor stages and observed that melanoma development within the dermis was accompanied by upregulation of molecules that can inhibit T cell function and by the concomitant loss of the CD11b+ dermal cDC2 population.