Since 2009, more than 60 mutations in fused in sarcoma (FUS), also known as translocated in liposarcoma (TLS), have been identified to be associated with the two overlapping adult-onset neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) [1, 2]. This evidence concerns the gene FUS and neurodegenerative disease.