SYNGAP1 and frontotemporal dementia: In particular, FUS has been shown to regulate the expression of synaptic proteins by binding to the 3′-UTR of the GluR1 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (encoded by Gria1) [30] and α2 isoform of synaptic Ras GTPase-activating protein 1 (SynGAP1) (encoded by Syngap1) [31], and transient FUS knockdown in hippocampus leads to behavioral abnormality related to FTD [30].