It has been demonstrated that water-soluble molecules secreted by breast cancer cells, such as α-SMA, TGF-β, IL-8, and MMP-3, could not only recruit ADSCs from adjacent tissues, but also promote the proliferation, proangiogenic factor secretion, and myofibroblastic differentiation of ADSCs and inhibit adipogenic differentiation of ADSCs, leading to extracellular matrix deposition and contraction [30]. The gene discussed is CXCL8; the disease is breast cancer.