Exosome isolated from gefitinib-treated EGFR-mutant NSCLC cells conditioned medium decreased the anti-neoplastic effects of cisplatin by increasing autophagic activity and reducing apoptosis, as confirmed by an increasing Bcl-2/Bax ratio, upregulation of LC3-II, and downregulation of p62 protein levels [59]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.