Circulating exosomal Integrin β4 (ITGB4) and vinculin (VCL) could predict taxane-resistance in prostate cancer patients [141]. Higher plasma levels of exomiRs (miR-1290 and miR-34a) are related to poor response to docetaxel in metastatic CRPC patients [142, 143]. The gene discussed is VCL; the disease is Familial prostate cancer.