ABCA3 and leukemia: For instance, in leukemia and lymphoma, it has been found that high expression of ATP-binding cassette transporter A3 (ABCA3) is crucial for exosome generation and chemoresistance and pretreatment of diffuse large B-cell lymphomas (DLBCL) with indomethacin, a COX inhibitor, enhances the accumulation of doxorubicin and pixantrone in the nuclei of DLBCL tumor cell through the reduction in ABCA3 levels and exosome biogenesis, which increases tumor cell susceptibility to these drugs [33].