However, in a later study, IL-22 expression was increased in both blood and kidney tissue samples from LN patients and MRL/lpr mice, demonstrating that the increased serum IL-22 levels cannot be due to the IL-22 status in LN, because serum expression of IL-22 would make a difference depending on the different pathogenic forms of LN [31]. This evidence concerns the gene IL22 and lobular neoplasia.