IL13 and asthma: Specifically, Hypo-EVs might decrease IL-13 levels in BALF from the mice with OVA-induced asthma through miR-146a-5p delivery; however, by using TargetScan analysis (http://www.targetscan.org/vert_72/), we found that miR-146a-5p had no binding site (conserved sites) with the 3′ untranslated regions of IL-13 (data not shown), which indicated that miR-146a-5p could not directly act on IL-13.