Eventually, the risk prediction model of breast cancer with 13 genes, including GSTK1, CORO1A, TRIM21, CD3E, GZMM, ADK, RAC1, GSTZ1, HCK, UBTF, ANXA5, GRHPR, CHP1, was generated and the coefficient of each independent prognostic gene was shown in Fig. 4b. The gene discussed is ANXA5; the disease is breast cancer.