We also compared the relative expression levels of ANXA5 between subgroups in breast cancer tissues, and found that luminal subtype was lower than TNBC (P = 0.007) and HER2 postitive (P = 0.003) subtypes, peri-menopause was higher than per-menopause (P = 0.028) and post-menopause (P = 0.002), and as the age progressed, the expression of ANXA5 decreased (all P < 0.05, Fig. 11d). The gene discussed is ANXA5; the disease is breast cancer.