Eventually, the risk prediction model of breast cancer with 13 genes, including GSTK1, CORO1A, TRIM21, CD3E, GZMM, ADK, RAC1, GSTZ1, HCK, UBTF, ANXA5, GRHPR, CHP1, was generated and the coefficient of each independent prognostic gene was shown in Fig. 4b. This evidence concerns the gene RAC1 and breast cancer.