Older age (≥ 40 years) at diagnosis of breast cancer (p = .04), larger tumor size (T2 and T3; p = .002), advanced baseline stage (III and IV; p < .0001), and HR positive HER2 positive subtype (p = .01) were more frequently found in patients who developed brain metastases as the first recurrence compared with those who had a first recurrence at other sites in the body [10]. This evidence concerns the gene ERBB2 and breast cancer.