To test this hypothesis, we tried to elucidate the potential biological processes and signaling pathways associated with LMNA mutation-associated DCM through deeply analyzing the chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq) datasets, which were obtained from the Gene Expression Omnibus (GEO) database. The gene discussed is LMNA; the disease is familial dilated cardiomyopathy.