For the differential genes associated LMNA alone with euchromatin, we obtained 5 candidate genes (EGR2, NMB, CREBBP, PRF1, and TENM4), of which EGR2 and NMB have been reported to involve in myocardial ischemia and heart failure, respectively [30, 31]. Here, PRF1 is linked to myocardial ischemia.