Interestingly, a research dedicated onto the spine and dendrite degeneration in spinocerebellar ataxia presented by Ruegsegger et al. identified HOMER3 as a downstream target of mTORC1 since ablation of mTORC1 signaling leads to reduced HOMER3 levels in cerebellar Purkinje cells and vice versa [37]. The gene discussed is HOMER3; the disease is cerebellar ataxia.