Other recurrent gains included FGFR4 (n = 4 [33%]), TERT (n = 3 [25%]), and CCNE1 (n = 3 [25%])—particularly relevant given the recent success of CDK inhibitors in hormone-positive disease and the burgeoning use of FGFR inhibitors against solid malignancies as we and others have reported [31, 73]. This evidence concerns the gene CCNE1 and glycogen storage disease VI.