These included gains and losses in shared pathway members, notably NTRKs and SFRPs, respectively; targetable upregulation of growth factor pathway mediators such as FGFR4 and EGF; and outlier gains in the CDK regulator CCNE1. Three of 12 cases also shared outlier expression gains in TERT, with case ERLR_14 harboring a particularly extreme enrichment from near undetectable levels in the primary tumor (Fig. 3b). Here, FGFR4 is linked to neoplasm.