NOTCH1 and acute lymphoblastic leukemia: CJ reduces the cell surface expression of NOTCH1 receptors and prevents the formation of the cleaved NICD1 molecules, which results in the transcriptional suppression of MYC and HES1. The authors also demonstrated that CJ is more active against HD-mutated T-ALL cells compared to a cell line carrying NOTCH1 juxtamembrane mutations such as Jurkat.