NOTCH1 and acute lymphoblastic leukemia: Hence, the consequent decrement on NICD1 level causes a Notch1 on-target inhibitory effect on leukemia growth in vitro, in T-ALL xenografts, and in a Drosophila intestinal stem cell model in which Notch1 inhibition perturbs differentiation of midgut pluripotent stem cells [35, 96].