GAN and neoplasm: The results reveal that cell proliferation and colony formation are significantly decreased when lnc-GAN1 is overexpressed in H460 and A549 cells, but is markedly increased when lnc-GAN1 is knocked down in H1299 and H1650 cells (Fig. 2c, d and Additional file 2: Fig. S1b-c), indicating that lnc-GAN1 can inhibit oncogenic growth of NSCLC cells and functions as a tumor suppressor, which is consistent with the result obtained in the above clinical analysis.