According to the analysis of DEGs, 31 genes involved in osteoarthritis susceptibility were identified, such as collagen alpha-1(I) chain (Col1a1), protein S100-A4 (S100a4), fatty acid-binding protein (Fabp4), collagen alpha-1(IV) chain (Col4a1), cyclic AMP-responsive element-binding protein 3-like protein 1 (Creb3l1), C-C motif chemokine 9 (Ccl9), retinoid-binding protein 7 (Rbp7), neurogenic locus notch homolog protein 3 (Notch3), C-X-C motif chemokine 16 (Cxcl16), and receptor activity-modifying protein 3 (Ramp3), as shown in Table 4. Here, S100A4 is linked to osteoarthritis.