Furthermore, we found that CpG ODN treatment decreased the expression of Wnt2b (Fig. 5c), the expression and nuclear translocation of β-catenin (Fig. 5d & e; Supplementary Fig. 5A&B), and the expression of Axin-2 in HCC-TAMs (Supplementary Fig. 5C). The gene discussed is WNT2B; the disease is hepatocellular carcinoma.