Consistently, compared with the HCC cells treated with the culture medium of control HCC-TAMs (Vector-CM), the expression of the mesenchymal markers and the EMT-related transcription factors was downregulated (Fig. 3b; Supplementary Fig. 3B) but E-cadherin/N-cadherin ratio was upregulated (Supplementary Fig. 3E) in HCC cells treated with the culture medium of Wnt2b-silenced HCC-TAMs (sh-Wnt2b-CM). The gene discussed is CDH2; the disease is hepatocellular carcinoma.