CTNNB1 and neoplasm: Subsequently, compared with mice inoculated with a mixture of SMMC-7721 cells and TAMs that were transfected with a vector, we found that tumour growth rate and tumour load were remarkably reduced in mice inoculated with a mixture of SMMC-7721 cells and TAMs that had either silenced Wnt2b or CTNNB1 (Fig. 7d-e).