We observed that both IL-10 and TGF-β can stimulate the expression of Wnt2b, β-catenin, and c-Myc in macrophages (Supplementary Fig. 7), suggesting that various factors in TME mediate the polarization of HCC-TAMs via Wnt2b/β-catenin signalling. Here, TGFB1 is linked to hepatocellular carcinoma.