The results showed that compared with the control HCC-TAMs, the expression of key glycolytic enzymes such as HK2, PGK1, PKM2, LDHA, and LDHB was downregulated in HCC-TAMs silenced Wnt2b or CTNNB1(Fig. 4a & b). This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.