This event allowed for the elimination of tumour-suppressive miR-375, thus promoting cancer cell growth. The inhibitory effect of miR-375 on gliomas was found to rely on the inactivation of the connectivetissuegrowthfactor (CTGF)-epidermalgrowthfactorreceptor (EGFR) signalling pathway. This evidence concerns the gene CCN2 and central nervous system cancer.