Furthermore, with high expression in all GBM (glioblastoma) subtypes, oncogenic miR-10b possesses strong therapeutic potential due to its regulatory function in AS by interacting with multiple SFs, including MBNL1 (muscleblind-like splicing regulator 1), MBNL2 and DGCR14 (DiGeorge syndrome critical region gene 14) [71, 137]. The gene discussed is ESS2; the disease is glioblastoma.