TPM1 and esophageal cancer: For example, the lncRNA TPM1-AS binds to the SF RBM4 and blocks the targeting of TPM1 pre-mRNA, leading to the inhibiting of TPM1 exon 2a inclusion and a decrease in the two tumorigenic splicing isoforms V2 and V7 and thus inhibiting migration and filopodium formation in esophageal cancer cells [88] (Fig. 5b).