EGOT can directly bind to the cis-acting element in ITPR1 pre-mRNA, resulting in the recruitment of the SF hnRNPH1 to promote hnRNPH1-mediated AS, contributing to the expression of the ITPR1 protein, which sensitizes cells to paclitaxel cytotoxicity in cancer therapy [46]. Here, HNRNPH1 is linked to cancer.