MALAT1-mediated SRSF1 phosphorylation can affect the subcellular localization of SRSF1 and promote splice site selection in AKAP-9 (A-kinase anchor protein 9) pre-mRNA [82–84], thus contributing to the expression of the AKAP-9 isoform, which exacerbates cellular proliferation, migration and invasion in CRC [80] (Fig. 5a). The gene discussed is SRSF1; the disease is colorectal carcinoma.