Recently, Peipert et al. selected a group of MEN1 affected adult US citizens (from an initial population of 207 MEN1 patients), analyzing their HRQoL compared to other chronic diseases, through PROMIS (Patient-Reported Outcomes Measurement Information System), an initiative that aimed to develop novel ways to measure patient-reported symptoms, such as pain and fatigue, and aspects of HRQoL across a wide variety of chronic diseases and conditions. The gene discussed is MEN1; the disease is multiple endocrine neoplasia type 1.