TP53 and colorectal cancer: The targets of PQDS-specific miRNAs were specially implicated in several additional pathways such as ECM-receptor interaction, fatty acid metabolism, forkhead box protein O (foxO) signaling, chronic myeloid leukemia, cell cycle, p53 signaling, central carbon metabolism in cancer, colorectal cancer and transcriptional misregulation in cancer (Fig. 3c right).