The targets of PQDS-specific miRNAs were specially implicated in several additional pathways such as ECM-receptor interaction, fatty acid metabolism, forkhead box protein O (foxO) signaling, chronic myeloid leukemia, cell cycle, p53 signaling, central carbon metabolism in cancer, colorectal cancer and transcriptional misregulation in cancer (Fig. 3c right). This evidence concerns the gene TP53 and chronic myelogenous leukemia, BCR-ABL1 positive.