MiR-142 downregulation could alleviate PTSD-like behaviors, such as anxiety, depression, and memory disorders, in rats exposed to SPS procedure by combing with FMRP, which might regulate the level of pre-inflammatory chemokines by affecting nuclear factor kappa-B (NF-κB) signaling and then affect synaptic function. The gene discussed is FMR1; the disease is post-traumatic stress disorder.