APP and Alzheimer disease: Additionally, the number of TH+ neurons in 12-month-old APP/PS1 mice was decreased compared with that of 12-month-old WT mice (123.4 ± 4.77 vs 88.18 ± 5.74, P = 0.0062, Fig. 5b), while LC-NE neuron numbers were similar between AD and WT mice at 3 months of age (130.8 ± 9.273 vs 127.5 ± 8.44, P = 0.99, Fig. 5b).