APP and Alzheimer disease: Importantly, the expression of Iba-1 was more pronounced in 12-month-old APP/PS1 mice compared to 24-month-old WT mice in PFC (5.42 ± 0.23 vs 12.62 ± 0.79, P < 0.0001, Fig. 1b), ACC (P < 0.0001, Fig. 1c), DG (P < 0.0001, Fig. 1d), and CA3 (P = 0.044, Fig. 1e), suggesting AD pathogenesis has a greater effect on microglial activation than otherwise healthy aging.