Greater Iba-1 expression in AD spinal cords were detected compared to that of age-matched WT mice, and there was a greater degree of Iba-1 expression in 12-month-old APP/PS1 mice compared to 24-month-old WT mice (24.15 vs 17.47, n = 6, P < 0.0001, Fig. 2). Here, APP is linked to Alzheimer disease.