General mechanisms of immunotherapy resistance involve intrinsic tumor biology, including lack of antigen presentation (i.e. lack of antigen expression or lack of antigen processing and presentation); T cell deprived environment (β-catenin, MAPK, etc.); a generalized suppressive microenvironment, and treatment-specific mechanisms (e.g. low PD-L1 expression or JAK2 mutation). Here, CD274 is linked to neoplasm.