OVV-CXCR4-Fc has a multifaceted effect, including direct oncolysis of CICs, decreased recruitment of suppressive elements promoting tumor vascularization, and stimulation of antitumor immunity monitored by the presence of humoral and cellular immune responses to Wilms’ tumor Ag 1 (WT1) expressed by ID8-T cells. The gene discussed is CXCR4; the disease is neoplasm.