In the CheckMate-227 study, median OS was 17.1 months with nivolumab plus ipilimumab and 14.9 months with chemotherapy (p = 0.007) in patients with advanced NSCLC and PD-L1 expression ≥ 1%; 2-year OS rates were 40 and 33%, respectively [20]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.