We propose that NEAT1-miR-212-3p/miR-132-3p/miR-129-5p-TTK (Fig. 8d) and XIST-miR-25-3p/miR-129-5p-GZMA (Fig. 8e) might be potential RNA regulatory pathways to regulate the disease progression of early RA. Here, XIST is linked to rheumatoid arthritis.