HLA-C and neoplasm: We further investigated the tumor antigen presentation capacity of the three phenotypes, and observed that TIME-3 had the highest APS and MHC-related molecules expression level, as opposed to TIME-1 (all, P < 0.01; Additional file 6: Fig. S4I and Fig. 4f), which was consistent with the CYT value and BCR/TCR diversity (all, P < 0.05; Fig. 4g–i and Additional file 6: Fig. S4J, K).