Moreover, high TSPO distribution was associated with post-treatment Lyme disease syndrome [20] and clinical stage and extent of tau aggregation in patients with Alzheimer’s disease [21], and patients with traumatic brain injury, especially repeated injuries, showed higher TSPO radioligand uptakes in the atrophic brain regions compared to the controls [22]. The gene discussed is TSPO; the disease is early-onset autosomal dominant Alzheimer disease.