Limitations of the study include 1) lack of information about other ASCVD-REFs such as lipoprotein (a), Apo B, viral infections including hepatitis B, C and, human immunodeficiency deficiency virus (HIV) 2) given the limited number of events, we pooled borderline and intermediate-risk as a single group and no sex-stratified analysis was performed, 3) The significant risk of HDP for hard CVD during a 10-year follow-up was not stable considering the limited number of events. The gene discussed is APOB; the disease is viral infectious disease.