CD274 and colorectal carcinoma: In this study, the “Nano-FdUMP + Nano-Folox” strategy was able to induce ICD-associated antitumor immunity, which significantly reprogrammed immunosuppressive TME, improving antitumor efficacy against MSS CRC liver metastasis (established by CT26-FL3 cells, an MSS CRC cell line [62, 63]) in combination with anti-PD-L1 mAb (fig.