The expression of p53, Caspase-9 and Caspase-3 was found to increase significantly, which was more significant than that of the free ISOIM, indicating that the pathway of NHL apoptosis induced by CCM@MSNs-ISOIM may induce tumor cell apoptosis through the p53 pathway. The gene discussed is CASP9; the disease is non-Hodgkin lymphoma.