A Western blotting analysis showed the accumulation of cleaved caspase-3 and poly(ADP-ribose)polymerase (PARP) in the AOM-DSS + ferrichrome group compared to the AOM-DSS + PBS group, suggesting that tumor cell apoptosis had been induced by ferrichrome treatment (Fig. 2c). The gene discussed is CASP3; the disease is infectious otitis media.