The AOM-DSS model showed that ferrichrome greatly reduced the tumor area, and Western blotting showed that the cleavage of caspase 3 and PARP was significantly induced in the ferrichrome treated AOM-DSS model, illustrating the anti-tumor effect of ferrichrome through the induction of apoptosis on colorectal cancer cells associated with the colitis-associated pathway. This evidence concerns the gene CASP3 and colorectal cancer.