With the loading of a photosensitive molecule indocyanine green (ICG), the ICG@FeDH holds potential to combine several advantages based on following considerations: first, the FeDH is constructed from organic molecules by strong covalent bonds, ensuring the excellent biocompatibility and colloidal stability under physiological condition; second, the iron ions can be doped into the nanoagent and render it with catalase-like activity, thereby overcoming the tumor hypoxia to improve the phototherapeutic efficacy. The gene discussed is CAT; the disease is neoplasm.