For instance, lncRNAs MEG3 and HOTAIR were found associated with the development of non-invasion PA (NIPA) into IPA, as evidence by the decrease in MEG3 level and increase in HOTAIR level during the development transformation of normal pituitary into NIPA and eventually into IPA tissues [9]; lncRNA H19 was up-regulated in IPA, and thereby could be used as a biomarker for PA diagnosis [10]; the knockdown of lncRNA AFAP1-AS1 could suppress cell growth and induce apoptosis in PA [11]; moreover, lncRNA SNHG1 had a high level in IPA and could activate the Wnt/beta-catenin pathway in IPA [12]. This evidence concerns the gene AFAP1 and Ito hypomelanosis.