CircHIPK3 was also significantly upregulated in CRC tissues and cell lines, and ectopic expression of circHIPK3 effectively reversed the miR-7-induced attenuation of the malignant phenotype of CRC cells by increasing the expression level of miR-7 targeting proto-oncogenes (FAK, IGF1R, EGFR, YY1) [94]. This evidence concerns the gene EGFR and colorectal carcinoma.