Western blot analysis of PlGF, β-catenin, C-myc and LDHA in tumor tissues revealed that depletion of PlGF caused significant reductions of protein levels of C-myc, β-catenin, and LDHA in shPlGF xenografts, which were in accordance with the results in H358 and H1975 cells (Fig. 6d). The gene discussed is PGF; the disease is neoplasm.