The results of GSEA for KEGG analysis showed that XPF expression was associated with Ubiquitin mediated proteolysis, oocyte meiosis, oocyte meiosis, TGF-β signaling pathway, renal cell carcinoma, adherens junction, long term potentiation, progesterone mediated oocyte maturation, small cell lung cancer, colorectal cancer, WNT signaling pathway and so on (Fig. 9c, d). Heat map of GO and KEGG results of GSEA was showed in Additional file 2: Figure S1. This evidence concerns the gene ERCC4 and renal cell carcinoma.