GSDME and neoplasm: We finally selected 12 genes (SLC5A5, SLC7A6, NFE2L2, DFNA5, VEGFC, MUM1, TRIB2, MCOLN1, FBP1, ACADM, WDR37, and NR3C1) that demonstrated a significant correlation with clinical prognosis (Table 4), and five independent clinical factors (age, pathologic_N, pathologic_T, targeted molecular therapy, and new tumour) for our predictive models (Table 5).