The 6 hypomethylation-imprinted genes were PEG10, NAP1L5, INPP5F, PLAGL1, NESP and MEG3, in which PEG10 decreased from 50.92% in control to 45.17% in CHD group (P < 0.01), NAP1L5 decreased from 68.86 to 62.12% (P < 0.01), INPP5F decreased from 73.17 to 67.02% (P < 0.01), PLAGL1 decreased from 42.80 to 40.97%,(P < 0.05), NESP decreased from 41.12 to 31.31% (P < 0.01), and MEG3 decreased from 45.31 to 39.53%(P < 0.01) (Fig. 1; Additional files 1–8: Figures S1–S8). The gene discussed is GNAS; the disease is coronary artery disorder.