Furthermore, ATF3 expression had a good performance in discriminating HCC across above four datasets (GSE14520: AUC = 0.6935, P < 0.0001; GSE25097: AUC = 0.8339, P < 0.0001; GSE76427: AUC = 0.7218, P < 0.0001 and GSE121248: AUC = 8506, P < 0.0001) (Fig. 3e–h). The gene discussed is ATF3; the disease is hepatocellular carcinoma.