Therefore, this study aimed (i) to assess the correlation of pro-metastatic genes ‒ CTTN, RhoA, ROCK, CLDN-1, CLDN-2, and CLDN-4 ‒ with clinicopathological parameters, (ii) to determine the inter-correlation of pro-metastatic genes in primary BrCa. This evidence concerns the gene CLDN4 and invasive breast carcinoma.