Therefore, this study aimed (i) to assess the correlation of pro-metastatic genes ‒ CTTN, RhoA, ROCK, CLDN-1, CLDN-2, and CLDN-4 ‒ with clinicopathological parameters, (ii) to determine the inter-correlation of pro-metastatic genes in primary BrCa. The gene discussed is CLDN2; the disease is invasive breast carcinoma.