Findings put emphasize on ROCK transcription as a contributor to ALNM of IDC -BrCa. The present findings indicated the overexpression of CTTN, CLDN-1, and CLDN-4 in association with advanced stages of primary non-metastatic BrCa, which is highly evident in  ER + status of breast tumors. This evidence concerns the gene CLDN4 and invasive breast carcinoma.