Overexpressed CTTN might induce the expression of S-phase kinase-associated protein-2 (SKP-2) to promote the cellular proliferation of head and neck squamous cell carcinoma [60], which was associated with larger tumor size observed in BrCa patients [62, 63]. Besides, cortactin-related SKP-2 signaling and subsequent down-regulation of cyclin-dependent kinase inhibitors might promote rapid cellular proliferation to result in increased tumor size. This evidence concerns the gene CTTN and invasive breast carcinoma.