CTTN and metastatic malignant neoplasm in the lymph nodes: The overexpression of CTTN was associated with lymph node metastasis [15–19], advanced histologic grades [16, 20, 21], and larger tumor size [15, 16] in various cancers suggesting that cortactin might have prognostic impacts on different cancers but less paid attention to BrCa. One study reported a significant correlation between the protein expression of cortactin and lymphatic metastasis of breast tumors  [22].