Studies have reported that circRNA circ_104718 [24], circRNA circ_CDR1AS [25], and circRNA circ_RHOT1 [26] play a cancerigenic role in HCC, but circRNA circ_5692 [27] and circRNA circ_TRIM33-12 [28] exert anti-tumor role in HCC. The gene discussed is TRIM33; the disease is neoplasm.