Because CDH13 promoter methylation is common in many human tumors, it has been suggested as an early detection and prognostic marker for human malignancies [27, 46, 49], particularly colorectal [40, 41], breast [34], and non-small cell lung cancer (NSCLC) [29, 32, 33]. The gene discussed is CDH13; the disease is non-small cell lung carcinoma.