MARCHF1 and type 2 diabetes mellitus: The present meta-analysis identified a genome-wide significant association to suppression of early glucagon secretion during OGTT for a locus containing MARCH1. Type 2 diabetes risk variant in the EYA2 locus associated with plasma glucagon levels at 30 min of the OGTT, while other variants influence glucagon levels without conferring increased type 2 diabetes risk.