Then clinical symptoms and signs such as fever, pneumonia, and occasional extrapulmonary manifestations such as skin rash, encephalopathy begin to appear, along with the involvement of other organ cells and associated elevations of AST, ALT, LDH, CRP, D-D and other biomarkers Therefore, early systemic immune modulators (dose-adjusted corticosteroids and/or high-dose intravenous immunoglobulin), may prevent rapid progression of pneumonia and induce rapid recovery of pulmonary lesions in M. pneumoniae pneumonia [11, 24]. This evidence concerns the gene CRP and susceptibility to pneumonia measurement.