SNP-rs428253 in EBI3 gene is related to the occurrence and development of CHD, which may be caused by regulating β—Catenin pathway and Treg pathway rather than by influencing the production of IL-35, because in the IL-35 levels was not different among different genotype of rs428253 in controls of study by Lin et al. [16]. The gene discussed is EBI3; the disease is coronary artery disorder.