TRIM63 and Stroke: Chen et al. (2017b) found in the study that compared with non-stroke animals, stroke mice have significantly lower heart EF, meanwhile, atrogin-1 and E3 ubiquitin ligase murf-1 were elevated, and the transcription factor peroxisome proliferative activated receptor was a potential mediator of transcriptional dysregulation in stroke-related myocardial atrophy (Veltkamp 2019).