CCL2 and stroke disorder: At the same time, stroke significantly increased macrophage infiltration and increased levels of Interleukin-1(IL-1), Interleukin-6(IL-6), Monocyte-chemoattractant protein-1(MCP-1), tumor necrosis factor-β(TGF-β) and macrophage-related inflammatory cytokines in the heart, and induced cardiac fibrosis (Yan 2020).