MAPT and Alzheimer disease: The histopathological changes occurring in AD brain can be divided into two processes: Firstly, the formation of extracellular plaques (senile plaques) by deposition of amyloid-beta and secondly, the intercellular tangles/neurofibrillary tangles (NFT’s) originating from paired helical filament (PHF) of microtubule-associated protein tau [101] (Figure 3).