MAP3K5 and metabolic dysfunction-associated steatohepatitis: Overall, PRRs activate several intracellular targets such as Transforming Growth Factor-β (TGF-β) activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1), both members of mitogen-activated protein kinase kinase kinases (MAP3K) family, which activate in turn other kinases such as c-Jun-N-terminal chinasi (JNK), adenosine monophosphate-activated protein kinase (AMPK) and IkB, hence with a key role in NASH pathogenesis [109,110,111].