The activation of TLRs, through the stimulation of JNK and NF-kB pathways, leads to different consequences, including among others, the production of Tumor Necrosis Factor-α (TNF-α) (able to induce the proliferation of tumor cells) as well as many other mediators involved in the recruitment and polarization of different inflammatory cell types [174,175,176,177]. Here, TNF is linked to neoplasm.