Cancer-associated fibroblasts (CAFs) can produce epidermal growth factor (EGF), hepatocyte growth factor (HGF), fibroblast growth factor (FGF), IL-6, IL-8, chemokine C-X-C motif ligand 12 (CXCL12), and matrix metalloproteases (MMP-3 and MMP-9) [179,191,192]. This evidence concerns the gene EGF and cancer.