These cells, in fact, through the secretion of cytokines (such as TGF-β and IL-10), chemokines, growth factors, and matrix metalloproteases, can contribute to fibrosis, tumor growth and progression, intrahepatic metastasis development, angiogenesis, and, most notably, immune suppression by promoting Th2-type immune response [182,183]. This evidence concerns the gene IL10 and neoplasm.