In pancreatic cancer, solute carrier family 39 member 4 (ZIP4) induces ZEB1 expression via STAT3 signaling and subsequently activate integrin α3β1 to regulate the JNK signaling pathway, leading to inhibit chemosensitivity by decrease gemcitabine transporter ENT1 [119]. This evidence concerns the gene STAT3 and familial pancreatic carcinoma.