In line with a role for RHOA inactivation in CRC, a recent publication demonstrates that upregulation of IRX5 in CRC goes along with inflammation (CXCL1, CXCL8 expression) and inactivation of RHOA/ROCK1/LIMK1, which correlates with poor prognosis [105]. The gene discussed is LIMK1; the disease is colorectal carcinoma.