ARHGAP17 and colitis: Moreover, RhoGTPase-activating protein 17 (Arhgap17) participates in the maintenance of tight junctions and vesicle trafficking; mice carrying ARHGAP17-deficient IECs have shown an increased paracellular permeability and defective localization of the apical junction, although this is not causing spontaneous colitis, but increased the sensitivity towards DSS-induced colitis [80].