In cancer, the Gly17Val RHOA mutation, which blocks the binding of GTP under guanine nucleotide exchange factor (GEF) stimulation, was found in all type of T-cell lymphoma, especially in angioimmunoblastic T-cell lymphoma (AITL) (53.3% or 68% [94,95]) and did not appear in any diffuse large B-cell lymphoma (DLBCL). Here, RHOA is linked to diffuse large B-cell lymphoma.