Interestingly, mutations in Rho- and Rac- pathway related genes (DOCK2, DOCK3, PREX2, RADIL) and other somatic mutations that activate/inactivate Rho GTPases were identified in 50% IBD-CRC, suggesting that non canonical WNT signaling can be a potential target in IBD [93]. The gene discussed is AKT1; the disease is inflammatory bowel disease.