As a matter of fact, alterations of RAB-mediated trafficking are pivotal in various aspects of both progression and tumorgenicity of cancer cells including the sustainment of proliferative signaling, the evasion of growth suppression, the induction of receptor recycling, the activation of invasion and metastasis as well as the reprogramming of tumor metabolism and the evasion of immune destruction [7,8]. Here, AGFG1 is linked to cancer.